Ubiquitin Enzymes Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Ubiquitin enzymes, is also termed by E2 enzyme and seldom as known ubiquitin-carrier enzymes. This helps to achieve the second successive step in the ubiquitination process that aims at a protein to cut into various segments through the proteasome. The ubiquitination process firmly attaches ubiquitin, which is a short protein consisting of 76 amino acids, to a lysine deposit on the essential protein to be targeted. Once a protein gets attached with any of the ubiquitin moiety, excess rounds of ubiquitination form a polyubiquitin chain that is approved by the proteasome's 19S regulatory element.

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Ubiquitin Enzyme will not only profit big pharma companies but also small to mid-sized players and academic institutions.

Globally, there are numerous studies and research groups trying to explain the unseen potential of extremely difficult regulatory structure in order to progress the viable drug compound. Many literatures studies in a short span of 1 year, nearly 1500 journals related to ubiquitin enzymes are being published since 2015. A number of procedural advances in ubiquitin enzyme had led to the enhancement and development of varied technological platforms, research based assessment, tool essentials, chemicals and pioneer compounds to help the different drug discovery programs in different academic and industry researchers. In fact, the current conclusive trend-lines from different literature studies explains that not only big pharma giants but also small scale to mid-sized players and academic institutions.

There are various strategic partnerships evolved and had linked various stakeholders to advance research and development processes in Ubiquitin Enzymes Market. The growing field of research has gained the attention of various venture capital firms and investors. The emerging market, mainly focus on cancer indication, is likely to flourish in the long term and observer the rise of several successful drugs.

Cancer under application segment to dominate the Ubiquitin Enzymes Market over the forecast period

The global ubiquitin enzymes market is segmented on the basis of product type, application and geography. On the basis of product type, the market is divided into E1 and E2 enzymes as therapeutic targets, E3 enzymes as therapeutic targets, dub enzymes as therapeutic targets and associated drug class. On the basis of application, the Ubiquitin Enzymes Industry is divided into cancer, biological engineering and others.

Increase in clinical trial success rate pushes pharmaceutical industries to invest more in ubiquitin enzyme studies

Regional segmentation of the ubiquitin enzymes market by Coherent Market Insights comprises North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. North America accounts for the largest share in the global ubiquitin enzymes market mainly due to increase in more number of research centers and presence of global pharma players which develop protein molecules for therapeutic activity process.

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More than 40 clinical trial molecules in pipeline is expected to boost growth of Ubiquitin Enzymes Market

Key players operating the ubiquitin enzymes market include 3SBio, 5AM Ventures, Abbiotec, Abcam, AcelRx Pharmaceuticals, Aegera Therapeutics, Aeneas Ventures, Agilis Biotherapeutics,  Aileron Therapeutics, Alexion Pharmaceuticals and Amgen among others. Major market players are constantly working on research and development, as the market is largely untapped and offer highly lucrative growth opportunities. For instance, ubiquitin pathway based inhibitors, there are over 45 molecules that are under development which are used to treat a variety of indications. Considering the disturbingly high incidence rate of cancer across the globe, the ubiquitin enzymes market is expected to ride on a wave of positive growth in the foreseeable future.

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Middle Ear Implants Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Middle Ear Implants Market Overview

Middle implant ear is a small device inserted into the middle ear and coupled to ossicles. Middle ear implants are devices designed for those who suffer mild- moderate mix or sensorineural hearing loss and conductive hearing loss. Middle ear implant is an advanced technology for the conventional use of hearing aid. A middle ear implant is recommended for people suffering from earmould allergies, skin problems, ear infections, collapsed or closed ear canals, etc. It can also serve as an alternative to bone anchored hearing aid. The difference between middle ear implant and other hearing aid is that it do not require a speaker. Middle ear implant transmits sound to the middle ear through the microphone placed behind the ear. The microphone converts sound to mechanical vibration and is sent to floating mass transducer placed in the middle ear.

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Middle ear implants are broadly classified as piezoelectric and electromagnetic. Piezoelectric products uses piezoelectric crystal, applied electric charge cause crystals to bend and the bend crystal generates electric charge that causes inner ear bones to vibrate. Electromagnetic product uses external microphone and send the signal through the coil and converts to magnetic field. Piezoelectric middle ear implant is expected to contribute major share to the overall middle ear implants industry. On the basis of type of hearing loss, market is segmented into conductive, sensorineural, and mixed.

Global middle ear implants market taxonomy

The global market is classified on the basis of the following segments:

• Product Type
• Piezoelectric Middle Ear Implant
• Electromagnetic Middle Ear Implant
• Type of Hearing Loss
• Conductive
• Sensorineural
• Mixed (conductive and sensorineural)
• End Users
• Hospitals
• Ambulatory Surgical Centers
• Specialized Clinic

Increasing Government Support in Developed Regions to Address Growing Prevalence of Hearing Loss to Augment Growth of Middle Ear Implants Market

Increasing concerns related to hearing loss is expected to drive growth of the market in middle ear implants. As per a WHO report, as of 2012, around 360 million people worldwide suffered from hearing loss, which accounts for around 5.3% of the world population. Out of the total hearing loss patient population, 91% were adults with children accounting for the rest. The increasing cases of hearing loss due to exposure to loud noise, trauma, viral infections, increasing geriatric population, and rising incidence of malformation of inner ear are expected to drive growth of the overall middle ear implants industry.  Increasing government regulations for early screening, diagnosis and treatment of hearing problems further augments growth of the middle ear implant market. In the U.S., Medicaid regulates one such program called the Early and Periodic Screening, Diagnosis and Treatment (EPSDT) Program. EPSDT is mandated for children from birth to till age 21, which provides beneficiaries for early screening, diagnosis and treatment of hearing aid. In Canada, hearing loss is covered under ICD-9 389.1 (Sensorineural Hearing Loss), 389.0 (Conductive Hearing Loss)—an initiative by various governmental and non-governmental organizations to spread awareness about early treatment on hearing loss. This creates a highly conducive environment for growth of the global middle ear implants market. On February 6, 2016, Public Affairs & Campaigns of the U.K. initiated a campaign to protect audiology services. On February 25, 2015, WHO started “Make Listening Safe Initiative” to mark March 3, 2015 as Ear care day to draw focus towards danger of unsafe listening, promote safe practices and early treatment. Increasing urbanization and development are one of the major factors to drive middle ear implants industry. Despite impetus to market growth from increasing number of cases of hearing loss being reported worldwide, the availability of alternative treatments such as Bone-anchored devices and Cochlear implants are expected to hinder growth of the market.

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North America and Europe are expected to hold maximum share of overall market, owing to growing disposable income and easy availability of middle ear implant device in these regions. On the other hand, Asia Pacific is projected to provide highly lucrative opportunities for market growth due to increasing geriatric population and growing number of cases of hearing loss reported each year.

Major middle ear implant products in the market:   

    

Esteem Hearing Implant (Envoy Medical), MAXUM Hearing Implant (Ototronix), cochlear implant (CI) system (MED-EL Corporation), Ossicular (middle ear) implant (Medtronic)

Major Players in the middle ear implants market

Major players involved in the middle ear implants market include Envoy Medical, Ototronix, MED-EL Corporation, Medtronic, CENTILLION and Cochlear.

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Orthopedic Trauma Devices Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Orthopedic Trauma Devices Market Overview

Orthopedic trauma is a condition that includes injuries mainly affecting the human skeleton and deteriorating the condition of the subject. It includes the conditions ranging from simple fracture to severe life threatening injuries that are caused due to accidents. Orthopedic trauma includes multiple broken bones across different parts of the body that involve extensive reconstructive surgery. Severe orthopedic traumas can only be treated by fracture specialists and specialized team of surgeons. Various equipment and devices play a key role in reconstructive surgeries. Orthopedic traumas include dislocations, sprains, connective tissue injuries, hematomas, and final to traumatic amputations.

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Orthopedic Trauma Devices Market Trends: Increasing Number of Cranial and Musculoskeletal Surgeries 

Fat embolism and compartment syndrome are some of the other conditions that can arise due to orthopaedic traumas. The human skeleton is broadly divided into two main sections, namely upper and lower extremity. As the name suggests the upper extremity includes the upper section of the body above the abdomen such as cranium, humorous, ulna, collar bone, spine, and wrist bones. Cranium is an important part of the skeleton that helps keep the nervous system protected. Treatment of orthopedic trauma such as cranial injury is a complex task that requires specialized devices and support system. Treatment options vary according to the type and severity of the condition. For instance, external fixation is a commonly used technique for skeletal immobilization through which, bones or their fragments are kept stationary to perform surgeries. Fixation involves insertion of nails and screws in the fractured pieces of bones to make them immovable.

Orthopedic Trauma Devices Market: Global Market Still Provides Significant Growth Potential

Though there are large number of specialized orthopedic hospitals, clinics and trauma centres across the globe, the market still holds lucrative growth opportunities. This is further augmented by increasing number of surgeries worldwide. According to National Model of Care for Trauma and Orthopaedic Surgery 2015, during patient’s stay in hospital, 86% of orthopaedic inpatients undergo primary surgery procedure and around 70% of this activity is focussed on lower limb surgery. 

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Orthopedic Trauma Devices Market: Cost Driven Market with Favourable Reimbursement Policies

Favourable reimbursement policies are the beneficial checkpoints of the orthopedic trauma devices market, as the cost for treatment in such cases is relatively high as compared to regular surgery. The reimbursement policies include some vital instruction in which, only evidence-based medicine should be prescribed for treatment apart from the devices used in the surgery that are branded and requires authentic make. Also, other expenditure such as patient transfer rates with healthcare changes should be as per protocol in order to decrease out-of-pocket expense by the patient. However, some factors that can slow down market traction in the near future are rise in cost of procedure, high cost of devices used in treating orthopaedic trauma cases, and low availability of super specialized professionals. Also, the dynamic nature of orthopedic branch is such that specialists involved need to constantly upgrade their skills and keep track of the changing practices. Sub-specialization has become commonplace and the market is characterized by an acute shortage of general orthopedic surgeons.

Market segmentation of orthopaedic trauma devices includes various categories, such as:

Product type, material type and end user

Orthopedic Trauma Devices Market by Product type

• Screws
• Self-drilling Screw
• Emergency Screw
• Plate
• 2 Hole, Straight Plate
• 6 Hole, Straight Plate
• Others
• Bone Cement
• Nails
• Others (Patient Specific Implants)

Orthopedic Trauma Devices Market by Material type

• Absorbable
• Non-Absorbable
• Titanium Stainless Steel

Orthopedic Trauma Devices Market by End User

• Orthopaedic Clinics
• Hospitals
• Emergency Medical Services

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Orthopedic Trauma Devices Market Future Outlook: Focus on Research and Development for Cost Effective Products

Some organizations involved in the manufacturing of the orthopaedic trauma devices also actively focus on research and development activities to introduce better and economical products. Increasing focus on strengthening the distribution channels is expected to further enhance availability of products in the market. Some of the key players in market are as follows:

• Biomet, Inc
• DePuy Synthes (a Johnson & Johnson)
• Braun Melsungen AG
• Medtronic
• Integra LifeSciences Corporation
• Stryker Corporation
• Zimmer Holding Inc.
• Smith & Nephew
• Orthofix International
• NuVasive

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Large Volume Wearable Injectors Market Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Larger volumes drug delivery require a new product concept, a large-volume wearable injector

Large volume wearable injectors are devices that are used to deliver high volume of drugs usually in the range of 2 – 10 ml of drug within 2 – 15 minutes. There are many chronic conditions, which require prolonged and continuous drugs delivery and introduction of wearable injectors are one of the achievement in the field of novel drugs delivery systems. Many global pharmaceutical companies are developing biologic therapeutics, which are basically rooted onto monoclonal antibodies for the treatment of autoimmune disorders and immuno-oncology drugs. With the busy lifestyle there is a low possibility of regular intake of drugs through injections, typically weekly, biweekly or monthly by people suffering from various chronic conditions that require constant medication. Wearable injectors offer the perfect solution in terms of portability and precise dosage administration.

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Drugs with longer half-lives, the pharma companies need think the pros and cons between injections and auto-injector and less common injections from a wearable injector

According to Vice-President, Corporate Development, Enable Injections, the increased cost to bring a single pharmaceutical drug into market, which is estimated to be around US$ 2.6 billion in 2015, is a huge expenditure for a new developing pharma company and have a greater burden to make the most of revenue and stay ahead of many pharma and medical device competitors. Pioneering products are high risk/high reward, with various companies focusing on developing first-in-class treatments, with only the most effective surviving in the market. The collaboration between various companies makes provides for highly lucrative opportunities for both large volume wearable injectors market and wearable medical devices market.

Adhesive patches injectors the leading product in the large volume wearable injector market

The global large volume wearable injectors market is segmented on the basis of injector, by usage, by injector mechanism, by therapeutic area, by end user, and geography. On the basis of type of injector, the market is divided into, on-body, off body and hand held. On basis of usage, the market is divided into disposable and reusable. On basis of injector mechanism, the market is divided into spring-based, pressurized gas, motor driven, rotary pump and expandable battery. On basis of therapeutic area, the large volume wearable injectors market is divided into oncology, diabetes, cardiovascular, auto-immune disorders, infectious disease and others. On basis of end user, the market is divided into hospitals, home care settings, clinics, and ambulatory surgical centers, and others.

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Collaboration of Pharma and Medical Devices companies to Put Large Volume Wearable Injectors Market on high growth trajectory 

Regional segmentation of the large volume wearable injector market by Coherent Market Insights comprises North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. North America to hold the major chunk of large volume wearable injectors as many medical device and pharma companies combined together has their research and development centers in U.S., which makes early accessibility of advanced technologies and higher penetration of health care services. For instance, Amgen launched a therapeutic product used to deliver the 70mg of drug every week and then the modification of product transformed weekly dose regime to monthly. This can be used with either a Prefilled Syringe or Auto Injector. With advancements in technology, the company developed a wearable injector, which was approved by US FDA and this device is available in the U.S. since 2016. The other factors fueling growth of the large volume wearable injector market are better marketing, efficacy in long term dosage, and predominantly the rising number of patients with chronic long-term disorders.

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Manufacturer’s Landscape Evolution - Becton Dickinson and West Pharma and heading towards the heading towards the pole position in Large Volume Wearable Injectors Market

Key players operating the large volume wearable injectors market include SteadyMed Therapeutics, Inc., Enable Injections, UNILIFE CORPORATION, Insulet Corporation, Sensile Medical AG, Becton, Dickinson and Company, West Pharmaceutical Services, Inc., Bühler Motor GmbH, Ypsomed, Amgen Inc., among others. Major pharma and medical companies in the market are constantly working towards introducing innovative products and lowering production costs as many large volume biologics are still under clinical trials. For instance in June 2016, Ypsomed self-care solution collaborated with Novo Nordisk to develop and provide new dimensions in insulin pump therapy.

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Gel Permeation Chromatography Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Gel permeation chromatography (GPC) or size exclusion chromatography is a kind of liquid chromatography technique that separates analytes based on their size. This chromatography technique employs a stagnant liquid as the stationary phase that is present in the pores of beads and a flowing liquid as the mobile phase. Historically, the porous medium used in GPC was composed of a gel. Hence, the term gel permeation chromatography (GPC). Since, GPC is convenient, reproducible, simple, rapid, and reliable, it is expected to be generally applicable in various biochemical as well as clinical research. Currently, the market for gel permeation chromatography is expected to grow significantly due to the exponentially growing biotechnology and pharmaceutical industry along with increasing application of chromatographic technologies in various sectors of the healthcare industry.

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The major types of gel permeation chromatography are as follows:

• Conventional gel permeation chromatography
• Multi-detector gel permeation chromatography

Based on components, the global gel permeation chromatography market is classified as follows:

• Pump
• Eluent
• Gel
• Injector
• Detector
• Data processing equipment

Increasing Research Activities in Asia Pacific Region to Fuel the Demand for Gel Permeation Chromatography

In terms of regional distribution, use of gel permeation chromatography market is high in North America and Europe due to increasing number of ongoing research initiatives and domicile preference of this market for launching new technology. Asia Pacific, Latin America and Middle East, on the other hand, are expected to be the potential markets in the near future. Increasing number pharmaceutical companies and biologics manufacturers along with high adoption rate of advanced technological platforms and exponentially growing healthcare industry in these regions is expected to propel demand for gel chromatography in the near future.

The Gel Permeation Chromatography Market Dynamics

Globally, the gel permeation chromatography market is witnessing a substantial development. Increasing incidence rate of chronic disorders such as cancer and other human genetic disorders that requires sophisticated technologies for purification and analysis of nucleic acids as well as proteins are expected to boost the growth of the gel permeation chromatography market in the near future. Furthermore, other factors such as high demand for improved therapeutics and personalized treatment plans for various disease indications are driving the growth of this market.

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Besides, increasing usage of sophisticated chromatographic techniques in the field of pharmaceutical and biotechnology industries along with incessant increase in novel product launches are further augmenting the growth prospects of this market. For instance, in January 2015, the U.K. based Malvern Instruments Ltd., launched a new fully integrated multi-detector gel permeation chromatography/size exclusion chromatography (GPC/SEC) platform, OMNISEC for delivering high performance and high productivity in various analytical laboratories. Hence, anticipated technological breakthroughs along with increasing number of research activities might drive the growth of the gel permeation chromatography market. However, high price of these chromatographic platforms and lack of skilled technician are some of the factors that might negatively influence the growth of the gel permeation chromatography market in the near future.

Fragmented Market to provide Opportunities for Small Players

Presently, the global gel permeation chromatography market is highly fragmented and competitive owing to the presence of many established players in the market. The market is expected to witness a significantly high growth due to increasing applications of metabolomics, proteomics and genomics in the field medicine and overall healthcare industry. Major companies operating in the field of gel permeation chromatography market are Agilent Technologies, GE Healthcare, Malvern Instruments Ltd., Shimadzu Corporation and Waters Corporation, amongst others.

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Regenerative Medicine Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Regenerative medicines are medical products or active pharmaceutical ingredients that have the ability to cure or replace organs and tissues organs damaged by various factors such as aging, diseases, trauma, and can also be used to provide stability in congenital disorders. According to findings of various studies, regenerative medicines can also be useful in treating both chronic and acute disorders in terms various context of abnormalities such as cardiovascular diseases, dermal wounds, and in treatment of certain types of cancer. Furthermore, the current therapy of organ and tissue transplantation for treating organ and tissue failures can result in patient death due to limited or no donor supply and often result in severe complications in immune system. Regenerative medicine helps alleviate such issues to a major extent.

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Furthermore, players in the regenerative medicine market focus on fueling growth in the pharmaceutical sector by adopting various strategies such as including the use of different materials in the preparation that can offer better results and newly generated cells or with the combination of both, in turn replacing the missing tissue and effectively serving its functions. The innate healing response of the human body can also be favored to support the regenerating activities. Age is a major factor that can affect the regeneration of the desired part, as the body’s ability to regenerate is low among adults as compared to young population or lower vertebrates. Materials play an important role in regeneration activities, as they form the basis of the growth and replacement, as they can mimic the native extracellular matrix (ECM) of tissues.

Regenerative medicine market taxonomy:

By Technology

• Biomaterial
• Tissue Engineering
• Stem Cell Therapy

By Product Type

• Cell-based products
• Acellular products

By Application

• Orthopedic & Musculoskeletal Disorders
• Cardiology
• Dermatology
• Diabetes
• Central Nervous System Disorders
• Others

By Material

• Algae Derived Alginate
• Synthetic Polymer
• Poly-lactide-coglycolide
• poly-ethylene glycol
• Hydrogels

By Agent Type

• Biologics
  • Autologous fibroblasts
  • Hematopoietic stem and progenitor cells
• Cell-based medical devices
  • Allogenic fibroblasts
  • Cell extraction
• Biopharmaceuticals
  • Tri-calcium Phosphate
  • Osteogenic Protein

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Rising number of bone and joint surgeries to fuel the growth of regenerative medicine market in the near future:

Rise in number of trauma case globally is expected to favor growth of the regenerative medicine market in the near future. There are different types of prosthetics and implants that are used to support the human body movement in case of trauma and severe injury. However, a majority of the young population perceives these to be an eye sore and are increasingly inclined towards non-obtrusive options that do not drastically alter their physical appearance and activities. Regenerative medicine provides a viable alternative to such conventional methods and also reduces risk of deformity. However, regenerative medicine is significantly expensive as compared to conventional methods of treatment. Also, this treatment option is barely effective for treatment of the geriatric population. These factors impede growth of the market to a certain extent. According to University of California, Los Angeles (UCLA) Department of Orthopedic Surgery, in 2015, around 7,515 orthopedic surgeries were conducted in the U.S. by the department from July 2014 to June 2015. This number is expected to rise due to rise in number of orthopedic trauma cases in the region, which is further projected to favor growth of the regenerative medicine market in the near future.

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Developed regions major growth engines of the regenerative medicine market

Developed countries such as the U.S., Germany, U.K., France, and Japan have a highly developed market for regenerative medicine, mainly due to technical advancements in the region. According to Regenerative Medicine Annual Report, in 2013, in regenerative medicine market there has been various product approvals along with annual revenue of around US$ 1 billion. Thus, this sector is expected to attract attention from investors and industry partners in the near future. Furthermore, as per the report, around 60,000 stem cell transplants are performed globally each year to treat various cancers and blood-based disorders. This augments growth of the market of regenerative medicine. Also, as observed by Alliance for Regenerative Medicine (ARM), in 2012, the bio-therapeutic companies distributing cell therapy products generated around US$ 900 million, with 160,000 patients undergoing various related treatments.

Major acquisitions to support growth of regenerative medicine market

There are few recent acquisitions by the big brands in biotechnology that is expected to favor growth of regenerative medicine industry. In August 2016, Medtronic Inc. acquired Heart Ware International, Inc. — a provider of technologies for less-invasive, miniaturized, mechanical circulatory support (MCS) for treatment of patients with advanced heart failure. This acquisition is further expected to favor the working efficiency of the company and broadens its product portfolio.  Key players operating in the regenerative medicine market include Deputy Synthes, Inc., Orthofix, Inc., NuVasive, Inc. and Zimmer Holdings, Inc.

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Cancer Biomarkers Market - Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Cancer is the second-leading cause of death worldwide (World Health Organization). There were around 14 million new cases of cancer reported across the globe in 2012 and the incidence rate is expected to increase by around 70% by 2030 (WHO). The most common cancer types are lung cancer, liver cancer, colorectal cancer, stomach cancer, and breast cancer.

Cancer therapies are expensive and the cost rises with increase in complexity or stage of the caner condition. Therefore, understanding cancer biomarkers is the key to developing the right treatment plan for a cancer patient. Biomarkers indicates one’s health condition and the underlying disease condition. Various types of biomolecules such as DNA, proteins, and hormones are widely used to detect the malady. These biomarkers can be found in blood, urine, stool, tumor tissue, or other body fluids. Different cancer biomarkers react differently to various cancer treatments. There are increasing efforts to diagnose cancer at an early stage, which would drive the global cancer biomarkers market growth. However, poor reimbursement policies is negatively impacting market growth.

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Cancer Biomarkers Market Taxonomy

The global cancer biomarkers market can be segmented on the basis of biomarker type, cancer type, application, and biomarker profiling technologies. On the basis of biomarker type, the market is segmented into protein biomarker, genetic biomarker and cellular biomarkers, and others.

On the basis of cancer type, the global caner biomarkers market is segmented into lung cancer, breast cancer, prostate cancer, cervical cancer, colorectal cancer and others. Human epidermal growth factor receptor 2 (HER2) is the biomarker highly targeted for breast cancer treatment. Other types of cancer biomarkers include ERCC1, BRCA1, BRCA2 and SPARC.

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On the basis of profiling technology, the market is segmented into omics technologies, imaging technologies, immunoassays, cytogenetic based tests, and bioinformatics. Omics technologies is widely used profiling technology in the global market. Growing demand for personalized treatment therapies, use of proteomics in cancer biomarker detection, growing demand for accurate & effective diagnostic procedures are amongst the major factors driving its market growth. Enzyme-Linked Immunosorbent Assay (ELISA) is the most widely used immunoassays profiling technology in the global cancer biomarkers industry.

On the basis of application, the market is classified as drug discovery and development, diagnostics, prognostics, risk assessment and others. Cancer biomarkers are finding increasing applications in drug discovery with growing research activities on targeted cancer therapies.

Cancer Biomarkers Market: Regional Overview

North America and Europe dominate the global cancer biomarkers market on account of high cancer diagnostic and detection procedures, high investment in research and development by pharmaceutical and biotechnology companies and better healthcare infrastructure supporting the R&D activities using biomarkers. Markets in emerging economies such as the Asia Pacific and Latin America are poised to grow at a considerable higher growth rate owing to increasing funding for cancer biomarker research, growing prevalence of cancer, increasing number of clinical trials and growing demand for targeted and personalized drug therapies. The WHO estimates that in 2015 only 35% of the low-income countries reported to have pathology services available in the public sector. The rate is extremely less compared the high-income countries, which reported 90% availability of pathology services. These factors highly govern the growth of cancer biomarkers market, as accessibility would enable uptake of this technology by the users.

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Some of the key players in the global cancer biomarkers market include Abbott Laboratories, Merck & Co. Inc., Affymetrix Inc., Agilent Technologies, Illumina, Inc., Roche Diagnostics Ltd, Becton Dickinson and Company, Thermo Fisher Scientific Inc., Qiagen NV, and Hologic Inc.

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Breast Biopsy Devices Market - Industry Insights, Trends, and Opportunity Analysis, 2016-2024

A breast biopsy is the removal of a sample of breast tissue or cells that is to be tested for breast cancer or any others breast related disorders. Breast biopsy is mainly preferred to detect breast cancer. The medic may recommend a biopsy when the female patient has an uncharacteristic lumps in the breast. A doctor may also recommend a breast biopsy when the patient has an abnormal change in the nipple such as any cellulite, congealing, scaling, or crusting of the skin. If a diagnostic test with the use of mammogram, ultrasound or MRI unveils an area or a region in the breast that appears with a lump in the breast, or in a nearby lymph node, a biopsy may be recommended.

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Vacuum-assisted breast biopsy is the dominating segment in the global breast biopsy devices market

Prevalence of breast cancer or suspicious lesions that might need a biopsy increases with age. Vacuum-assisted breast biopsy (VABB) are widely used owing to their low price and quick response time as compared to other diagnostic devices such as ultrasound, x-ray, computed tomography (CT), or magnetic resonance imaging. For instance, according to Hologic, C.R. Bard and Mammotome Company, VABB accounts for 90% of its revenue in the breast biopsy devices. Some of the other factors driving the market for breast biopsy devices market are increasing level of awareness. The American Cancer Society, Inc, advises men and women to attend self-awareness exams conducted through the year, which helps individual to detect any change in their breast which would be further diagnosed by the physician. Higher incidence of breast cancer is also attributed to increasing exposure to toxic chemicals. According to Occupational Safety and Health Agency (OSHA) and the National Institute of Occupational Safety and Health (NIOSH), in the U.S., around 50,000 workers die each year as a result of past exposure to hazardous agents. However, high procedure cost and side effects such as bleeding and infections post-procedure are some of the factors restraining market growth for breast biopsy devices.

VABB and fine aspiration needles contribute major share in breast biopsy devices market

The global breast biopsy devices market is segmented on the basis of product type, procedure type, technology, end user, and geography. On the basis of product type, the market is divided into biopsy needles, biopsy tables, biopsy wires, and guidance systems.

On the basis of procedure type, the market is segmented into fine needle aspiration (FNA) biopsy, core needle biopsy, surgical biopsy and biopsy markers. Core needle biopsy is sub-segmented into stereotactic core needle biopsy, vacuum-assisted biopsies and magnetic resonance imaging biopsy guidance; surgical biopsy is sub-segmented into incisional biopsy and excisional biopsy.

On the basis of guidance technology, the market is divided into ultrasound-guided, mammography-guided and magnetic resonance.

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On the basis of end user, the market is classified into hospitals, ambulatory surgical centers, diagnostic centers, research laboratories, and others.

Increasing breast cancer cases in North America a highly lucrative market

Regional segmentation by Coherent Market Insights comprises North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. North America accounts for the largest market share, mainly due to presence of major players and early adoption of advanced medical technologies in countries such as the U.S. and Canada. In 2015, according to Susang Komen—a non-profit organization that focuses on breast cancer awareness—there were over 2.3 million breast cancer cases diagnosed in the U.S. According to The European Breast Cancer Coalition, in EU-28 361,600 cases of breast cancer were reported in 2012, and 1 in 8 women in the EU-28 are projected to develop breast cancer before the age of 85. Europe is the second-largest market, owing to large target population—especially comprising elderly people who are more susceptible to diseases due to weakening immune system—along with high acceptance of VABB devices for diagnosis of breast cancer. Growing disposable income and increasing awareness level among the populace in Asia Pacific, along with a large population base is expected to position Asia Pacific as a high growth market in the near future. According to International Association of Cancer Registries, in 2012, over 600,000 new breast cancer cases were reported in Asia, accounting for 39% of all breast cancers diagnosed worldwide.

Hologic is one of the major company for breast biopsy devices market

Key players operating the breast biopsy devices market include Biomed Diagnostics, Inc., Bard Peripheral Vascular Inc., F. Hoffmann-La Roche Ltd., Hologic Inc., Intact Medical, Mammotome, OncoCyte Corporation and Laboratory Corporation of America Holdings (Labcorp), among others. Major companies in the market are constantly working towards introducing innovative products and lowering production costs in order to enhance profitability. For instance, in the recent times C. R. Bard expanded the use of its devices by offering reusable biopsy handles for free when disposable biopsy needles are purchased.

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